Does Ginkgo biloba work?

Does Ginkgo biloba work?

Like all herbal remedies, Ginkgo biloba extract contains a large number of active compounds that have therapeutic, pharmacological and medicinal value. These active compounds include flavone, ginkgolide B, and bilobalide components exert concentration-dependent antioxidant, metabolic, antidepressant, antiplatelet, and neurotransmitter regulatory effects that modulate cerebrovasculature, receptor/ transmitter activity, glucose metabolism, and electroencephalographic activity (Diamond and Bailey, 2013).

The ginkgo biloba tree seeds and leave also contain antimicrobial substances that kill the bacteria and fungi that cause infection in the body. It seems to improve the blood circulation, which helps the brain, ears, eye, and legs to function properly and to relieve pain. Ginkgo leaf extracts also shown to improve short-term visual memory and speed of mental processing in non-demented people with age-related memory loss. Improving thinking in young people is another important aspect of this plant. Some studies have been reported that a combination of ginkgo and Panax ginseng is more effective for improving memory than alone. Painful response to cold, especially in the fingers and toes (Raynaud’s syndrome), is mitigated by taking ginkgo (Isah, 2015).

Research claims that taking ginkgo leaf extract by mouth seems to decrease the number of painful attacks per week in people with Raynaud’s syndrome. Leg pain when this plant also treats walking due to poor blood flow (claudication and peripheral vascular disease). Taking ginkgo leaf by mouth also significantly reduces the symptoms of vertigo and dizziness. Ginkgo biloba has antioxidant activities, to increase tolerance to hypoxia, and to improve blood rheology by increasing the flexibility of cellular blood components, thus enhancing microcirculation; neurotransmitter levels; enhancing neuroplasticity; prevention of brain edema; and neuroprotection (Nash and Shah, 2015).

Ginkgo biloba is one of the most well-known dietary supplements in the world for improving mental health and preventing from large numbers of disorders such as anxiety, dementia and migraines. Although Ginkgo biloba is considered safe and healthy, you should take precautions with all herbal treatments. Ginkgo biloba may interact with different some drugs and medications (Rajarajan et al., 2018). It is important to take proper care to avoid possible interactions with other drugs or medications, which can lead to serious complications.

 Unlike medication, standard doses for the ginkgo biloba have not been established. There is inadequate information available to determine the best dosage. The standard dosage mostly depends on the desired outcomes. Ginkgo biloba mostly comes in the form of liquid extract, colas, capsules, extracts, sprays or tablets. You should follow all the instruction and warnings on the package of your ginkgo biloba to avoid any side effects. Doses between 120 and 240 mg take two or three times per day are considered optimal in most cases for cognitive and cardiovascular disorders. Experts suggest starting at a low dose of 120 mg per day and then increasing gradually (Kleijnen and knipschild, 2017). Always get advice from your doctor or physician for an acceptable dosage to avoid the negative effects of overdosage.

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Diamond, B. J., & Bailey, M. R. (2013). Ginkgo biloba: indications, mechanisms, and safety. Psychiatric Clinics, 36(1), 73-83.

Isah, T. (2015). Rethinking Ginkgo biloba L.: Medicinal uses and conservation. Pharmacognosy reviews, 9(18), 140.

Kleijnen, J., & Knipschild, P. (1992). Ginkgo biloba. The Lancet, 340(8828), 1136-1139.

Nash, K. M., & Shah, Z. A. (2015). Current perspectives on the beneficial role of Ginkgo biloba in neurological and cerebrovascular disorders. Integrative medicine insights, 10, IMI-S25054.

Rajarajan, G., Priyadorshoni, S. P., & Geetha, R. V. (2018). A review on the medicinal properties of Ginkgo biloba. Drug Invention Today, 10.